Some €15,000 in cash and gold items were stolen from the Cospicua parish church during the night.
The theft was discovered this morning when a priest and the sacristan went to the church to open it for Mass just after 6.30am.
It is believed that the thieves made use of scaffolding just outside the church to break into the church.
Donation boxes were broken and the money taken away, as were gold objects that were found in the church.
The police are investigating and a magisterial inquiry is under way.