The Sevilla crowd was ready to erupt when forward Luis Muriel appeared free from markers inside the area, with the ball in perfect position for his header just a few meters (yards) from the goal.

From that spot, there was surely nothing Manchester United goalkeeper David De Gea could do to keep the hosts from opening the scoring.

Only, there was.

De Gea came up with a spectacular one-handed reflex stop, quickly stretching out his right arm to parry the ball over the crossbar and stun both Muriel and the local fans.

It was the highlight of another solid performance by De Gea, and it helped United hold Sevilla to a 0-0 draw in their first-leg match in the last 16 of the Champions League on Wednesday.

"It was in the last minute of the first half so it was an important moment of the game," De Gea said. "I made a save and I'm happy for that."

Muriel had nobody close to him when he jumped near the six-yard (meter) line but his firm header wasn't placed far enough from De Gea and the goalkeeper made him pay.

In disbelief, the Colombian forward embraced the left post and closed his eyes for a few moments.

"I lament that missed chance," Muriel said. "I could have gone for the corner but I decided to strike it harder instead of placing it. De Gea is a great goalkeeper and made a great save."

A few moments before Muriel's header, De Gea had already been forced to tip a header by Steven N'Zonzi over the crossbar. He also stopped a long-range shot by Muriel by making a difficult diving save close the ground.

The scoreless result left the tie open heading into next month's second leg in Manchester, when Sevilla will be trying to make it to the quarterfinals for the first time and United will look to return to the last eight after three seasons.

In the night's other game, Shakhtar Donetsk came from a goal down to beat Roma 2-1 after midfielder Fred netted the winner with a perfect free kick in the 71st minute.

It was another solid defensive performance by United, which has kept nine clean sheets in its last 11 matches in all competitions. Jose Mourinho's team has the best defense in the Premier League with 19 goals conceded in 27 matches.

"I think the only moment where we felt relieved was in the last couple of minutes in the first half where (we had) a couple of mistakes in possession and they had a couple of good situations with two David great saves," Mourinho said. "We have one match to decide everything at Old Trafford."

Sevilla, a five-time Europa League winner, hadn't been held to a scoreless draw at its Ramon Sanchez-Pizjuan Stadium in 62 consecutive matches in European competitions, dating back to 2005. De Gea became the first visiting goalkeeper to keep Sevilla from scoring in a Champions League match at Sanchez-Pizjuan.

Sevilla coach Vincenzo Montella had warned ahead of the match that his strikers had to improve in front of goal because missed chances could be costly against United's defense. He had complained about the team's wasted chances in recent matches.

"I'm happy with the personality shown by the team but we should have scored a goal or two after creating so many chances," he said. "But we have to be satisfied because it's still wide open."

In one of United's few chances, forward Romelu Lukaku had a goal disallowed for controlling the ball with his arm before finding the net from inside the area with about 10 minutes left.

Mourinho raised some eyebrows by leaving Paul Pogba on the bench but had to bring the midfielder on less than 20 minutes into the match because of an injury to Ander Herrera.

Roma could be left ruing a poor second-half performance after allowing Shakhtar Donetsk to come from a goal down to win 2-1 in the first leg of their Champions League last-16 meeting Wednesday.

Cengiz Under continued his fine run of form by giving Roma the lead shortly before halftime but Facundo Ferreyra leveled for Shakhtar shortly after the break and Fred showed why some of Europe's top clubs are reportedly after him with a perfect free kick in the 71st minute.

"I seem to have seen two different Roma teams today on the pitch. After conceding the first goal I should have substituted most of them," Roma coach Eusebio Di Francesco said. "In the first half the team played to attack and then they played to manage I don't know what. For that reason I'm angry.

"I can't think we were presumptuous when winning, it's not as if Roma gets to the final every year. But in the second half we were too sloppy in our passing, something which we were perfect in in the first half."

Roma's players were similarly disappointed, with captain Daniele De Rossi admitting they "stopped playing" after Shakhtar's equalizer and the result "leaves us with a bitter taste."

Midfielder Diego Perotti couldn't believe his team's transformation after the break.

"What happened between the first and second half? I don't know, I'm asking myself that too," Perotti said. "Based on our first-half performance we deserved to win, and I'm very upset about the wretched second half we played. It's all our fault, there are no excuses, we're responsible."

Roma dominated the first half but it was the Italian club's Alisson who was the busier of the two goalkeepers, especially as the match wore on.

"We didn't actually start the game too badly, and even created a good chance, but didn't have a player to poke the ball in," said Shakhtar coach Paulo Fonseca. "Later there was a problem with our positioning. Roma were aggressive while our lines were stretched. We sorted this after the break and that helped us win.

"The team performed well in the second half. It wasn't easy to keep up that pace after a long winter break. The only reason we didn't win by a bigger margin was a brilliant display from the Roma keeper."

Manchester United goalkeeper David de Gea was also kept busy as he helped his side to a 0-0 draw in the night's other match.

Shakhtar is playing its home matches in Kharkiv, as the stadium in Donetsk was damaged by the conflict in Ukraine.

There were early chances for both sides with Roma going the closest but Edin Dzeko saw his attempt parried from close range by Andriy Pyatov, who then did well to kick away the ball.

Roma started to take control and took a deserved lead four minutes from halftime. Dzeko put in a perfectly-weighted pass to Under, whose finish bounced off Pyatov and into the far side of the net.

It was the 20-year-old Turkey winger's fifth goal in four matches and the perfect way to mark his Champions League debut.

Shakhtar defender Serhiy Kryvstov was then taken off on a stretcher before the break with a badly sprained ankle and had to be replaced by Ivan Ordets.

However, the home side leveled six minutes after the interval thanks to a mistake from Alessandro Florenzi, who had started the match despite a flu bug.

The Roma midfielder missed Yaroslav Rakitskiy's through ball, allowing Ferreyra to latch onto it and run around Manolas to fire past Alisson.

Alisson pulled off a number of good stops, including a brilliant save to fingertip Taison's effort away, but could do nothing to prevent Fred's 20-yard free kick from going into the top right corner.

Shakhtar almost extended its lead in stoppage time but Bruno Peres did well to clear Ferreyra's effort off the line.

 

It was another impressive result for Shakhtar, which beat Manchester City and Napoli in Ukraine in the group stages of this season's competition.