Derby came from two goals down for the second time against Southampton to eliminate the Premier League club from the FA Cup on Wednesday, winning a penalty shootout following a 2-2 draw in their third-round replay.

Derby captain Richard Keogh converted the decisive spot kick to secure a 5-3 win in the shootout after Nathan Redmond missed the only penalty for Southampton by shooting wide.

Southampton, which also led 2-0 in the teams' first 2-2 draw on Jan. 5, looked to be headed for the fourth round after Stuart Armstrong and Redmond scored in the 68th and 70th minutes to put the Premier League side in control. But Harry Wilson pulled one back with a free kick in the 76th and Martyn Waghorn equalized six minutes later to send the game to extra time.

Redmond also missed a good chance to restore Southampton's lead in the 111th minute, shooting straight at goalkeeper Kelle Roos after being slipped in by Oriol Romeu, before his off-target spot kick in the shootout proved decisive.

It was the Championship club's second penalty shootout win against a Premier League side this season after stunning Manchester United in the League Cup in September, giving first-year manager Frank Lampard another memorable cup victory.

Derby's preparation for this game was dominated by the fallout from Leeds coach Marcelo Bielsa admitting that he had sent a staff member to spy on Lampard's team in training ahead of their meeting last week in the Championship.

Lampard refused to comment on the matter before kickoff.