Lionel Messi scored twice and set up two more goals as Barcelona beat Lyon 5-1 to reach the Champions League quarterfinals on Wednesday.

After a 0-0 draw in the first leg, Luis Suarez ensured Barcelona was up 2-0 by halftime by earning a penalty converted by Messi and setting up Philippe Coutinho to score.

Lyon's Lucas Tousart gave the visitors hope with a goal in the 58th minute, but Messi scored again in the 78th before passing for Gerard Pique and Ousmane Dembele to round off the win.

In Wednesday's other game, Sadio Mane scored twice as Liverpool advanced with a 3-1 win at Bayern Munich.

Meanwhile, Sadio Mane scored twice to send Juergen Klopp's Liverpool into the Champions League quarterfinals with a 3-1 win at Bayern Munich in the second leg of the last-16 on Wednesday.

Mane opened the scoring with a delicate finish in the 26th minute and added Liverpool's third in the 84th by heading in Mohamed Salah's cross as Bayern desperately sought a way back into the game.

Serge Gnabry had forced an own goal from Joel Matip to equalize in the 39th, but Liverpool went ahead again through a corner when Virgil Van Dijk met James Milner's cross with a thumping header in the 69th.

The first leg in Liverpool was scoreless.

Klopp, who previously coached Bayern's old foe Borussia Dortmund, led the away fans' celebrations after the final whistle.

Also Wednesday, Barcelona defeated Lyon 5-1 at home to progress.