A weary Rafael Nadal and a wayward Roger Federer were knocked out of the quarterfinals of the Western & Southern Open, while No. 1 Novak Djokovic needed three sets to scrape into the semifinals.

Playing a day after he spent five hours on court, Nadal faded in a 6-3, 6-4 loss to American Mardy Fish, who had never beaten the second-ranked Spaniard.

Later, the third-seeded Federer struggled with his groundstrokes during a 6-2, 7-6 (3) loss to Tomas Berdych, who has won three of their past four matches

Djokovic survived a match of long rallies and electrifying shots, beating France’s Gael Monfils 3-6, 6-4, 6-3, while Andy Murray advanced with a 6-3, 6-3 win over Gilles Simon of France.

In the wide-open women’s tournament, second-seeded Vera Zvonareva, No. 4 Maria Sharapova and No.9 Andrea Petkovic advanced in straight sets. Jelena Jankovic moved into the semifinals when Peng Shuai withdrew with a sore left hip.

Fish, the highest-ranked American on the tour at No. 7, will play fourth-seeded Andy Murray in the semifinals, while Djokovic will take on Berdych.

Monfils broke Djokovic’s serve to open the match and set the tone. He made spectacular shots - Djokovic even patted his racket in appreciation - while pulling ahead 4-3 in the second set. Djokovic broke him to go up 5-4 and finally take control. The Serb broke him again to start the third set, and again to finish it.

“In the first set, he was down in concentration,” Monfils said. “Then he got into it and it was tougher.”

In the injury-depleted women’s bracket, the fourth-seeded Sharapova advanced easily with a 6-3, 6-2 win over 10th-seeded Samantha Stosur. Sharapova, who lost in last year’s final to Kim Clijsters, won a challenge on match point to improve to 3-0 this year and 9-0 in her career against the Australian.

“I did many good things today that caused her a lot of trouble,” Sharapova said. “I didn’t give her much time to do the things she likes to do.”

Stosur had got a day of rest Wednesday when her opponent, Serena Williams, dropped out of the tournament because of a sore big toe. She reached the quarterfinals, but couldn’t get that breakthrough win against Sharapova.

Sharapova’s semifinal opponent will be Russian compatriot Zvonareva, who beat Daniela Hantuchova 6-3, 7-6 (6). Petkovic defeated unseeded Nadia Petroiva 7-5, 6-1 and will face Jankovic, who advanced when Peng withdrew shortly before the scheduled start of their match.