Tottenham will head to Georgia to play Dinamo Tbilisi in the Europa League playoffs, and Fiorentina makes a short trip to play Grasshoppers in Switzerland.
Swansea, the other Premier League club in Friday's 62-team draw, is at home first against Petrolul Ploiesti of Romania.
Udinese of Serie A will host Slovan Liberec in the first leg.
In other ties, two-time winner Sevilla is away first against Slask Wroclaw, and Stuttgart travels to Rijeka.
Feyenoord, another two-time champion, travels to Russia to play Kuban Krasnodar in the first leg.
Dynamo Kiev begins in Kazakhstan against Aktobe.
First-leg matches are played Aug. 22, return matches are Aug. 29.
Winners advance to the group stage which will be drawn in Monaco on Aug. 30.