Marija Lourdes Bonnici and her daughter Angele Bonnici have been reported missing, the police said.
They were last seen at their Ghaxaq home on Tuesday 26 March, at around 7am.
Anyone with information about the missing persons can pass it on to the police, even in a confidential manner, on telephone numbers 21224001 or 119.
Information can also be passed on to officers at the Zejtun police station.