Barcelona is using its latest setbacks in the Spanish league as extra motivation for the game Tuesday against Atletico Madrid in the quarterfinals of the Champions League.

After having its 39-game unbeaten streak halted by a loss to rival Real Madrid this weekend, Barcelona turns its focus to the European tournament trying to remain upbeat.

"For a long time we didn't know what it felt like losing," Luis Enrique said Monday. "I hope that it serves as motivation to help us start winning again, just like we had been doing in recent months. I'm optimistic."

Barcelona had been cruising all season, scoring with ease and rarely being threatened but its supremacy was put in doubt after enduring two consecutive games without a victory - a 2-2 draw at Villarreal and the 2-1 loss to Madrid.

"We enjoy these challenges," Barcelona defender Gerard Pique said ahead of the match at the Camp Nou. "After a bad game, we all want to play again and give everything we have. Nobody has more confidence than we do right now."

It's the second time Barcelona and Atletico meet in the quarterfinals of the Champions League. The teams faced off in the 2013-14 season, when Atletico held Barcelona to a 1-1 draw in the first leg at the Camp Nou and won 1-0 in Madrid to advance to the semis. Diego Simeone's team eventually lost to Real Madrid in the final.

Atletico is coming off an emphatic 5-1 win over Real Betis in the Spanish league that left the club only six points behind Barcelona with seven rounds left.

"It will be even harder than it was on Saturday (against Real Madrid,)" Pique said. "Atletico is the second-best team in Spain if you look at the Spanish league."

Bayern Munich hosts Benfica for the first leg of their Champions League quarterfinal on Tuesday, aiming to leave the second leg a mere formality in reaching the club's fifth consecutive semifinal.

Confidence is high among Bayern's players and fans of getting past the Portuguese league leader and moving another step closer to repeating the 2013 feat of Champions League, Bundesliga and German Cup victories.

Benfica is bidding to reach the final four for the first time since 1990.

"Benfica is a team that you simply have to beat," former Bayern coach Ottmar Hitzfeld said. "I can't imagine that Benfica can put Bayern in danger. Bayern will pass this test with flying colors."

The sides met three times before in European competition. Bayern prevailed on the three occasions. The German powerhouse has won all nine of its previous two-legged knockout ties against Portuguese opposition.