Juventus continued its march toward a fifth successive Serie A title as it beat relegation-threatened Palermo 4-0 to move nine points clear on Sunday.
Sami Khedira gave Juventus the lead in the 10th minute but Palermo kept pushing for an equalizer before Paul Pogba and Juan Cuadrado sealed the result shortly after the 70th minute. Substitute Simone Padoin added a fourth late on.
Second-place Napoli lost 2-0 at Inter Milan on Saturday. There are five rounds left.
The only negative note for Juventus was an injury picked up by Claudio Marchisio who was stretchered off in the 15th with a knee injury. There are fears the Italy midfielder could miss the European Championship.
Earlier, third-place Roma missed the chance to close the gap to Napoli to three points as it drew 3-3 at Atalanta.
Roma is four points above Inter in the race for the final Champions League qualifying place, with Fiorentina two points further back after a 3-1 win over Sassuolo - thanks in part to a comical own goal from visiting goalkeeper Andrea Consigli.
At the other end of the table, a stoppage-time winner from Alessandro Frara gave Frosinone a crucial 2-1 victory at bottom side Hellas Verona.
Frosinone leapfrogged two points above Palermo and one behind Carpi, which occupies the last position of safety in Serie A.
Chievo Verona drew 0-0 at Udinese. Later, AC Milan's new coach Cristian Brocchi takes charge of his first match in his senior managerial career, at Sampdoria. Also, Lazio hosts Empoli.
Juventus knew that victory would leave it with one hand on the trophy and it seemed to be going to plan when Khedira chested down Pogba's chipped pass and volleyed it over Stefano Sorrentino.
Juventus appeared shocked by Marchisio's injury and lost its rhythm, allowing Palermo to create pressure, although Pogba did have an effort tipped onto the crossbar by Sorrentino.
Palermo almost leveled when Franco Vazquez sent Aleksandar Trajkovski through and although his shot beat Juventus goalkeeper Gianluigi Buffon, defender Andrea Barzagli got back to clear off the line.
It took Juventus until the 71st minute to double its lead when a corner came through to the back post for Pogba to tap in.
Cuadrado sealed the match three minutes later after a delightful dummy and Padoin completed the rout, stroking an Alvaro Morata assist into the far bottom corner.
In Florence, Gonzalo Rodriguez opened the scoring and Josip Ilicic restored that lead after a Domenico Berardi equalizer, to set Fiorentina on the way to ending a run of six matches without a win.
The result was sealed when Sassuolo goalkeeper Consigli went to kick an innocuous backpass to a teammate as it rolled gently toward him but somehow scuffed his shot so badly that he turned it into his own net.