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Wahbi Khazri set up a second-half goal and then scored one of his own to help Tunisia secure its first victory in a World Cup in four decades.
The Tunisia captain's hard, rising shot in the 66th minute lifted his team to a 2-1 triumph over Panama. It came 15 minutes after Khazri's pin-point pass led to Fakhreddine Ben Youssef's equalizer.
Tunisia had not won a World Cup game since a 3-1 victory over Mexico in 1978.
Panama held a 1-0 lead at halftime because of an own-goal in which Jose Luis Rodriguez's hard shot deflected off of defender Yassine Meriah in the 33rd minute.