Vincenzo Montella is hoping it is fourth time lucky as Sevilla attempt to overcome Manchester United and reach the Champions League quarterfinals.

Sevilla travel to Manchester having drawn 0-0 with Jose Mourinho's men at the Ramon Sanchez Pizjuan on February 21 in the first leg of their Champions League round of 16 tie.

It was seen as a missed opportunity for Sevilla, given they controlled much of the game and saw Luis Muriel denied a goal by a remarkable David de Gea save just before half-time.

Sevilla's Nolito attends a training session at Old Trafford, Manchester, England, Monday, March 12, 2018. Sevilla will play Manchester United in a Champions League round of 16, second leg soccer match on Tuesday. (Martin Rickett/PA via AP)

United have won all three of their matches since drawing in Seville, including coming from 2-0 down to beat Crystal Palace 3-2 and Saturday's 2-1 triumph over in-form Liverpool.

The La Liga side have failed in their three previous attempts to progress from the competition's last-16, including falling at this stage against Leicester last season.

Sevilla's only dalliance with the European Cup quarterfinals came in 1958 and Montella is hoping to make history at Old Trafford, having put in a promising display as the first leg ended 0-0.

Sevilla's Steven Nzonzi attends a training session at Old Trafford, Manchester, England, Monday, March 12, 2018. Sevilla will play Manchester United in a Champions League round of 16, second leg soccer match on Tuesday. (Martin Rickett/PA via AP)

"It is a big opportunity for us,'' said the Italian, who will be without former Manchester City wide man Jesus Navas through injury.

"We'll be playing 100 percent to try and achieve that.

"We know it's a tough task and we're going to suffer throughout the 90 minutes or longer.

Sevilla goalkeeper Sergio Rico attends a press conference at Old Trafford, Manchester, England, Monday, March 12, 2018. Sevilla will play Manchester United in a Champions League round of 16, second leg soccer match on Tuesday. (Martin Rickett/PA via AP)

"It's a very special game tomorrow night for Seville. It is a very important game for us.

"To keep going and try to get through to the quarterfinal would be great for us.

"It's a big comp, it would be the first time in 60 years for us to get through to this stage.

"We know we've got to score first and foremost to get through, but we have a lot of confidence in our ability.

"We know it's going to be tough, it's a very competitive even-stevens game.''